Synthesis and antibacterial activity of novel carbapenems with a catechol or hydroxypyridone moiety.

in chemotherapy. Recently there are manyreports detailing with /Mactams containing the catechol moiety1~5). In addition, it has also been reported that the introduction of a monoor dihydroxypyridone moiety6~ 12) instead of a catechol group as an isostere is effective in improving stability against catechol-0-methyltransferase (COMT)6). Such compounds show marked activity against Gramnegative organisms, in particular Pseudomonas aeruginosa. Apparently these iron-chelating groups allow /Mactams to behave as a siderophore mimic13'14). This characteristic enhances penetra-